Ionis Pharmaceuticals Inc (IONS)vsRegeneron Pharmaceuticals Inc (REGN)
IONS
Ionis Pharmaceuticals Inc
$54.21
-2.59%
HEALTHCARE · Cap: $9.65B
REGN
Regeneron Pharmaceuticals Inc
$781.49
-1.48%
HEALTHCARE · Cap: $80.46B
Smart Verdict
WallStSmart Research — data-driven comparison
Regeneron Pharmaceuticals Inc generates 1677% more annual revenue ($15.53B vs $874.09M). REGN leads profitability with a 27.9% profit margin vs -64.7%. REGN appears more attractively valued with a PEG of 1.31. REGN earns a higher WallStSmart Score of 66/100 (B-).
IONS
Avoid20
out of 100
Grade: F
REGN
Strong Buy66
out of 100
Grade: B-
Intrinsic Value Comparison
Multi-model valuation · Graham Formula
Margin of Safety
+36.7%
Fair Value
$133.22
Current Price
$54.21
$79.01 discount
Margin of Safety
+44.4%
Fair Value
$1404.34
Current Price
$781.49
$622.85 discount
Key Strengths & Concerns
Side-by-side fundamental analysis
Key Strengths
No standout strengths identified
Strong operational efficiency at 33.1%
Conservative balance sheet, low leverage
Safe zone — low bankruptcy risk
Large-cap with strong market position
Keeps 28 of every $100 in revenue as profit
Reasonable price relative to book value
Areas to Watch
Weak financial health signals
Expensive relative to growth rate
Trading at 20.4x book value
ROE of -66.5% — below average capital efficiency
Weak financial health signals
Earnings declined 4.5%
Comparative Analysis Report
WallStSmart ResearchBull Case : IONS
IONS has a balanced fundamental profile.
Bull Case : REGN
The strongest argument for REGN centers on Operating Margin, Debt/Equity, Altman Z-Score. Profitability is solid with margins at 27.9% and operating margin at 33.1%. Revenue growth of 16.7% demonstrates continued momentum.
Bear Case : IONS
The primary concerns for IONS are Piotroski F-Score, PEG Ratio, Price/Book. Debt-to-equity of 5.50 is elevated, increasing financial risk.
Bear Case : REGN
The primary concerns for REGN are Piotroski F-Score, EPS Growth.
Key Dynamics to Monitor
IONS profiles as a turnaround stock while REGN is a growth play — different risk/reward profiles.
IONS carries more volatility with a beta of 0.42 — expect wider price swings.
REGN is growing revenue faster at 16.7% — sustainability is the question.
IONS generates stronger free cash flow (549M), providing more financial flexibility.
Bottom Line
REGN scores higher overall (66/100 vs 20/100), backed by strong 27.9% margins and 16.7% revenue growth. IONS offers better value entry with a 36.7% margin of safety. Both earn "Strong Buy" and "Avoid" ratings respectively — the choice depends on your investment horizon and risk tolerance.
This analysis is generated from publicly available financial data. Not financial advice.
Ionis Pharmaceuticals Inc
HEALTHCARE · BIOTECHNOLOGY · USA
Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapies in the United States. The company is headquartered in Carlsbad, California.
Visit Website →Regeneron Pharmaceuticals Inc
HEALTHCARE · BIOTECHNOLOGY · USA
Regeneron Pharmaceuticals, Inc. is an American biotechnology company headquartered in Westchester County, New York. Originally focused on neurotrophic factors and their regenerative capabilities, giving rise to its name, the company then branched out into the study of both cytokine and tyrosine kinase receptors.
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