WallStSmart

Johnson & Johnson (JNJ)vsKrystal Biotech Inc (KRYS)

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Smart Verdict

WallStSmart Research — data-driven comparison

Johnson & Johnson generates 22451% more annual revenue ($99.33B vs $440.48M). KRYS leads profitability with a 54.8% profit margin vs 16.2%. KRYS trades at a lower P/E of 40.3x. KRYS earns a higher WallStSmart Score of 65/100 (C+).

JNJ

Buy

54

out of 100

Grade: C-

Growth: 4.7Profit: 8.5Value: 3.7Quality: 5.5
Piotroski: 3/9Altman Z: 2.64

KRYS

Buy

65

out of 100

Grade: C+

Growth: 7.7Profit: 9.0Value: 4.7Quality: 9.0
Piotroski: 4/9Altman Z: 8.02

Key Strengths & Concerns

Side-by-side fundamental analysis

Key Strengths

JNJ3 strengths · Avg: 8.7/10
Market CapQuality
$657.68B10/10

Mega-cap, among the largest globally

Operating MarginProfitability
25.7%8/10

Strong operational efficiency at 25.7%

Free Cash FlowQuality
$6.36B8/10

Generating 6.4B in free cash flow

KRYS6 strengths · Avg: 9.3/10
Profit MarginProfitability
54.8%10/10

Keeps 55 of every $100 in revenue as profit

Operating MarginProfitability
49.0%10/10

Strong operational efficiency at 49.0%

Debt/EquityHealth
0.0110/10

Conservative balance sheet, low leverage

Altman Z-ScoreHealth
8.0210/10

Safe zone — low bankruptcy risk

Revenue GrowthGrowth
24.1%8/10

Revenue surging 24.1% year-over-year

EPS GrowthGrowth
38.8%8/10

Earnings expanding 38.8% YoY

Areas to Watch

JNJ4 concerns · Avg: 2.8/10
Price/BookValuation
8.2x4/10

Trading at 8.2x book value

Piotroski F-ScoreQuality
3/93/10

Weak financial health signals

PEG RatioValuation
3.072/10

Expensive relative to growth rate

P/E RatioValuation
41.5x2/10

Premium valuation, high expectations priced in

KRYS1 concerns · Avg: 2.0/10
P/E RatioValuation
40.3x2/10

Premium valuation, high expectations priced in

Comparative Analysis Report

WallStSmart Research

Bull Case : JNJ

The strongest argument for JNJ centers on Market Cap, Operating Margin, Free Cash Flow. Profitability is solid with margins at 16.2% and operating margin at 25.7%.

Bull Case : KRYS

The strongest argument for KRYS centers on Profit Margin, Operating Margin, Debt/Equity. Profitability is solid with margins at 54.8% and operating margin at 49.0%. Revenue growth of 24.1% demonstrates continued momentum.

Bear Case : JNJ

The primary concerns for JNJ are Price/Book, Piotroski F-Score, PEG Ratio. A P/E of 41.5x leaves little room for execution misses.

Bear Case : KRYS

The primary concerns for KRYS are P/E Ratio. A P/E of 40.3x leaves little room for execution misses.

Key Dynamics to Monitor

JNJ profiles as a mature stock while KRYS is a growth play — different risk/reward profiles.

KRYS carries more volatility with a beta of 0.50 — expect wider price swings.

KRYS is growing revenue faster at 24.1% — sustainability is the question.

JNJ generates stronger free cash flow (6.4B), providing more financial flexibility.

Bottom Line

KRYS scores higher overall (65/100 vs 54/100), backed by strong 54.8% margins and 24.1% revenue growth. Both earn "Buy" and "Buy" ratings respectively — the choice depends on your investment horizon and risk tolerance.

This analysis is generated from publicly available financial data. Not financial advice.

Johnson & Johnson

HEALTHCARE · DRUG MANUFACTURERS - GENERAL · USA

Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. Its common stock is a component of the Dow Jones Industrial Average and the company is ranked No. 36 on the 2021 Fortune 500 list of the largest United States corporations by total revenue. Johnson & Johnson is one of the world's most valuable companies, and is one of only two U.S.-based companies that has a prime credit rating of AAA, higher than that of the United States government.

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Krystal Biotech Inc

HEALTHCARE · BIOTECHNOLOGY · USA

Krystal Biotech, Inc., a clinical-stage biotechnology company, is dedicated to the field of redosable gene therapy to treat serious rare diseases in the United States. The company is headquartered in Pittsburgh, Pennsylvania.

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