WallStSmart

Taysha Gene Therapies Inc (TSHA) Stock Analysis — PE Ratio, PS Ratio, Intrinsic Value & 2030 Price Target

Taysha Gene Therapies Inc stock (TSHA) is currently trading at $4.58. Taysha Gene Therapies Inc PS ratio (Price-to-Sales) is 121.40. Analyst consensus price target for TSHA is $11.29. WallStSmart rates TSHA as Sell.

  • TSHA PE ratio analysis and historical PE chart
  • TSHA PS ratio (Price-to-Sales) history and trend
  • TSHA intrinsic value — DCF, Graham Number, EPV models
  • TSHA stock price prediction 2025 2026 2027 2028 2029 2030
  • TSHA fair value vs current price
  • TSHA insider transactions and insider buying
  • Is TSHA undervalued or overvalued?
  • Taysha Gene Therapies Inc financial analysis — revenue, earnings, cash flow
  • TSHA Piotroski F-Score and Altman Z-Score
  • TSHA analyst price target and Smart Rating
TSHA

Taysha Gene Therapies Inc

NASDAQHEALTHCARE
$4.58
$0.45 (10.90%)
52W$1.05
$6.02
Target$11.29+146.5%

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WallStSmart

Smart Analysis

Taysha Gene Therapies Inc (TSHA) · 7 metrics scored

Smart Score

26
out of 100
Grade: F
Avoid
Investment Rating

Category Performance

WallStSmart pulls financial metrics like revenue growth, profit margins, and valuation ratios and scores each one from 0 to 10 based on how strong or weak it is. Those 10 scores are grouped into 4 categories: Growth, Profitability, Valuation, and Quality — which form the 4 axes of the spider chart you see. The categories are then combined into a final score out of 100, but not equally. Growth and Profitability together count for 60% of the total, because a fast-growing profitable business matters more than just a cheap one. That final number maps to a rating (Strong Buy, Buy, Hold, Avoid) and a letter grade, giving you one clear Stock Rating.

Investment Thesis

Strong fundamentals in revenue growth, institutional own.. Concerns around return on equity and operating margin. Significant fundamental concerns warrant caution or avoidance.

Taysha Gene Therapies Inc (TSHA) Key Strengths (2)

Avg Score: 10.0/10
Revenue GrowthGrowth
171.30%10/10

Revenue surging 171.30% year-over-year

Institutional Own.Quality
95.41%10/10

95.41% of shares held by major funds and institutions

Supporting Valuation Data

TSHA Target Price
$11.29
143% Upside

Taysha Gene Therapies Inc (TSHA) Areas to Watch (5)

Avg Score: 1.8/10
Return on EquityProfitability
-68.40%0/10

Company is destroying shareholder value

Operating MarginProfitability
-516.00%0/10

Losing money on operations

Price/SalesValuation
121.402/10

Very expensive at 121.4x annual revenue

Price/BookValuation
5.502/10

Very expensive at 5.5x book value

Market CapQuality
$1.19B5/10

Small-cap company with higher risk but more growth potential

Supporting Valuation Data

Price/Sales (TTM)
121.4
Overvalued
EV/Revenue
154.6
Overvalued

Taysha Gene Therapies Inc (TSHA) Detailed Analysis Report

Overall Assessment

This company scores 26/100 in our Smart Analysis, earning a F grade. Out of 7 metrics analyzed, 2 register as strengths (avg 10.0/10) while 5 fall into concern territory (avg 1.8/10). The category breakdown reveals uneven performance, with some areas requiring attention.

The Bull Case

The strongest argument centers on Revenue Growth, Institutional Own.. Growth metrics are encouraging with Revenue Growth at 171.30%.

The Bear Case

The primary concerns are Return on Equity, Operating Margin, Price/Sales. Some valuation metrics including Price/Sales (121.40), Price/Book (5.50) suggest expensive pricing. Profitability pressure is visible in Return on Equity at -68.40%, Operating Margin at -516.00%.

Key Dynamics to Monitor

Three factors to monitor going forward. First, whether Return on Equity improves, as this is the primary drag on the overall score. Second, margin trajectory, with Return on Equity at -68.40% needing improvement to support the investment thesis. Third, growth sustainability, with Revenue Growth at 171.30% strong but requiring continuation.

Risk Considerations

Based on the metric profile, this is a higher risk investment. There are more areas of concern than strength, warranting a more conservative position size. Investors should size positions according to their risk tolerance and maintain diversification.

Bottom Line

Fundamental challenges outweigh strengths at current levels. Return on Equity and Operating Margin are the primary drags. Consider waiting for meaningful improvement before committing capital.

Disclaimer: Smart Analysis is a scoring system developed by WallStSmart Team. Scores update daily using multi-model valuation framework. Always conduct your own research and consult with financial advisors before making investment decisions.

TSHA Price-to-Sales(PS) Ratio Chart

Historical valuation based on market cap ÷ trailing 12-month revenue

TSHA's Price-to-Sales ratio of 121.40x sits near its historical average of 114.37x (60th percentile), suggesting the market is pricing in steady-state growth. The current valuation is 65% below its historical high of 345.96x set in Sep 2023, and 363% above its historical low of 26.24x in Jan 2024. Over the past 12 months, the PS ratio has expanded from ~63.4x, reflecting growing market expectations outpacing revenue growth.

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WallStSmart Analysis Synopsis

Data-driven financial summary for Taysha Gene Therapies Inc (TSHA) · HEALTHCAREBIOTECHNOLOGY

The Big Picture

Taysha Gene Therapies Inc is in a high-growth phase, prioritizing rapid expansion over margins. Revenue reached 10M with 171% growth year-over-year. The company is currently unprofitable, posting a 0.0% profit margin.

Key Findings

Strong Revenue Growth

Revenue growing at 171% YoY, reaching 10M. This pace significantly outperforms most BIOTECHNOLOGY peers.

Heavy R&D Investment

Spending 252% of revenue (25M) on R&D, reinforcing its commitment to innovation and future growth.

Negative Free Cash Flow

Free cash flow is -27M, meaning the company is burning cash. This may be acceptable for high-growth companies investing heavily.

What to Watch Next

Growth sustainability: can Taysha Gene Therapies Inc maintain 171%+ revenue growth, or will competition slow it down?

Sector dynamics: monitor BIOTECHNOLOGY industry trends, competitive moves, and regulatory changes that could impact Taysha Gene Therapies Inc.

Bottom Line

Taysha Gene Therapies Inc is a high-conviction growth story with revenue accelerating at 171% while profitability is still developing. For growth-oriented investors, the trajectory is compelling. For value investors, the thin 0.0% margins and premium valuation suggest patience until the unit economics mature further.

This synopsis is generated from publicly available financial data. It is not financial advice. Always conduct your own research and consult a qualified financial advisor before making investment decisions.

Insider Transactions(18 last 3 months)

Total Buys
8
Total Sells
10
Feb 4, 2026(1 transaction)
ALAM, KAMRAN
CHIEF FINANCIAL OFFICER
Sell
Shares
-1,655

Data sourced from SEC Form 4 filings

Last updated: 8:23:14 AM

About Taysha Gene Therapies Inc(TSHA)

Exchange

NASDAQ

Sector

HEALTHCARE

Industry

BIOTECHNOLOGY

Country

USA

Taysha Gene Therapies, Inc., a gene therapy company, focuses on the development and commercialization of adeno-associated virus-based gene therapies for the treatment of monogenic diseases of the central nervous system. The company is headquartered in Dallas, Texas.